Graphdiyne advancing well

New Graphdiyne advancements Graphdiyne getting into health. Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemo-therapy Combination Treatment of Cancer jun jin, Mengyu Guo, Jiaming Liu, Jing Liu, Huige Zhou, Jiayang Li, Liming Wang, Huibiao Liu, Yuliang Li, Yuliang Zhao and Chunying ChenACS Applied Materials & Interfaces Publication Date (Web): February 19, 2018 https://doi.org/10.1021/acsami.7b17219 Nowadays, two-dimensional (2D) materials have attracted extensive attention as cancer drug delivery platforms, owing to their unparalleled physicochemical properties and superior specific surface area. Graphdiyne (GDY) is a novel 2D carbon material. Compared to graphene, GDY not only has benzene rings composed of sp2 hybridized carbon atoms, but also has acetylene units composed of sp hybridized carbon atoms, therefore it possesses multiple conjugated electronic structures. Herein, we used doxorubicin (DOX) as a model drug to develop a GDY nanosheet-based drug delivery platform for a photothermal/chemo-therapy combination in living mice. With a high photothermal conversion ability and drug loading efficiency, GDY/DOX under an 808 nm laser irradiation showed a much higher cancer inhibition rate compared with solo therapy both in vitro and in vivo. Furthermore, GDY exhibited great biocompatibility and no obvious side effects, as shown by histopathological examination and serum biochemical analysis. For the first time, our work demonstrated a successful example of GDY for efficient photothermal/chemo-therapy and suggests both safety and great promise for GDY in cancer treatment.